GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7267979 | 1 | rs6115168 | chr20:25372891 | PYGB | chr20:25228706-25278647:+ | 0.16 | 4.03 | 6.5E-5 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115182 | chr20:25410259 | ENTPD6 | chr20:25176339-25207360:+ | 0.32 | 7.43 | 4.95E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115182 | chr20:25410259 | FAM182A | chr20:26035250-26067552:+ | 0.18 | 3.44 | 0.000631 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115182 | chr20:25410259 | FAM182B | chr20:25744102-25848786:- | -0.25 | -5.25 | 2.33E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115182 | chr20:25410259 | NINL | chr20:25433338-25566153:- | 0.34 | 7.11 | 4.21E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115182 | chr20:25410259 | PYGB | chr20:25228706-25278647:+ | 0.15 | 3.78 | 0.000175 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115191 | chr20:25440478 | ENTPD6 | chr20:25176339-25207360:+ | -0.31 | -7.06 | 5.79E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115191 | chr20:25440478 | FAM182A | chr20:26035250-26067552:+ | -0.19 | -3.49 | 0.000526 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115191 | chr20:25440478 | FAM182B | chr20:25744102-25848786:- | 0.24 | 4.99 | 8.32E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115191 | chr20:25440478 | NINL | chr20:25433338-25566153:- | -0.37 | -7.51 | 2.94E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115191 | chr20:25440478 | PYGB | chr20:25228706-25278647:+ | -0.13 | -3.36 | 0.00084 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs73086581 | 1 | rs6116130 | chr20:3947026 | MAVS | chr20:3827449-3856761:+ | -0.23 | -3.54 | 0.000436 | Response to antidepressants in depression |
| THCA | cis | rs3796352 | 1 | rs61172708 | chr3:52996052 | RFT1 | chr3:53122503-53164470:- | 0.62 | 7.15 | 3.23E-12 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs3796352 | 1 | rs61172708 | chr3:52996052 | TMEM110 | chr3:52867139-52931547:- | 0.36 | 4.1 | 4.84E-5 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs2129782 | 1 | rs61177731 | chr8:89435708 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |